Total gastrectomy combined with splenectomy for the treatment of advanced gastric cancer systematic reviews.pdf
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The purpose of systematic evaluation of total gastrectomy combined with splenectomy for the treatment of advanced gastric cancer the effectiveness and safety. Methods We searched PubMed, EMBASE, Cochrane Library, Chinese Biomedical Literature Database, the Chinese Journal Full-text databases, full-text database of Chinese scientific and technical journals, manual searches to collect information on related magazines total gastrectomy combined splenectomy (TGS) and total gastrectomy (TG) in two different surgical treatment of advanced gastric cancer of the randomized controlled trials,Cochrane systematic reviews in accordance with the method of the study's methodological quality assessment, RevMan4.2.10 software used for statistical analysis. The results were included in two randomized controlled trials in patients with a total of 394 cases, the study of comparable baseline data are reported without mentioning blind randomized method and allocation concealment.Meta analysis showed that two groups of 1,3,5-year survival rate and complication rate was no statistically significant difference [OR (95% CI) were 0.98 (0.61, 1.58), 1.41 (0.95, 2.10), 1.29 (0.86, 1.29), 1.79 (0.98, 3.25)],However, infectious complications were statistically significant differences (P <0.05). Conclusions of the current study showed that total gastrectomy combined with splenectomy for the treatment of advanced gastric cancer increases the incidence of infectious complications, do not improve the survival rate does not affect mortality. Therefore, unless the transfer of spleen cancer or for a thorough dissection of spleen and splenic artery do door-positive lymph nodes, should be avoided in advanced gastric cancer total gastrectomy combined splenectomy.
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All languages:English Chinese (Simplified) Chinese (Traditional)
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